New Paradigm In Treating Catheter-Associated Urinary Tract Infections
Addressing the problem
It is no secret that Catheter-Associated Urinary Tract Infections (CAUTIs) which are extremely virulent, are very difficult to treat and eradicate. With a 5% cumulative chance of bacteriuria per day of a fitted catheter, we can assume within 1 month of a catheter fitting the patient has developed a bacterial infection. Many approaches have been tried but to date no reliable solution has emerged in preventing initial or recurrent CAUTI incidence in catheterised patients. With around 90,000 patients in the UK living with a long-term indwelling catheter and CAUTI bacteraemia leading to a 13-33% mortality rate, it has never been more crucial to address this issue.
How to Combat CAUTIs?
CAUTIs are the most common cause of gram-negative bacteraemia in hospitalised patients and are responsible for 40% of Hospital-Acquired Infections (HAIs).  Some of the most common pathogens to cause CAUTIs include Escherichia coli, Proteus mirabilis and Candida species, which can be attained externally by the handling of the catheter and the drainage system.
It is all very well knowing the ‘repeat offenders’ in terms of CAUTI causation to establish treatment, however bacteria have never been predictable, and resistance has been shown to change over the years. For example, E. coli have grown increasingly resistant to ciprofloxacin and co-amoxiclav while enterococcal resistance to ciprofloxacin has risen two-fold.  Thus, finding a broad-range, non-selective solution is paramount, which poses the question: would we have more success preventing the CAUTI in incidence rather than the continued struggle to produce a cure?