This research explored the potential of NanoVibronix technology to enhance epidermal and dermal structures in human skin explants. The research was performed at BIO-EC laboratory, Paris, FRANCE
The goal – explore the potential of NanoVibronix technology in stimulating regeneration of epidermal and dermal structures of human skin explants.
The evaluation methods – Observation of general morphology and visualization of different biological precursors or indicators after immuno- staining.
Explants were put into six wells culture plate and treated by one of four protocols:
Treatment with intermittent mode induces marked increase cytokeratin 14, slight increase in neutral GAGs and Collagen III, while a decrease in Ki67 and Collagen IV was observed
Treatment with intermittent mode induces a significant increase of approx. 75% and 80% in epidermal thickness and CK14 expression in comparison to the untreated explants, respectively.
According to these results, Nanovibronix stimulation with intermittent mode induces a very clear epidermal stimulation with a good cellular morphology compared to the Retinol Tx.
Stimulation with intermittent mode induces:
These results show that treatment with Nanovibronix’s ultrasound technology in intermittent mode has a clear epidermal activity and a slight neutral GAGs stimulation close to the dermal epidermal-junction indicating enhancement of skin tissue regeneration.